منابع مشابه
Diagnostic value of TLE1 for synovial sarcoma: immunohistochemical analyses of genetically confirmed synovial sarcomas and nonsynovial sarcomas
Synovial sarcoma is a relatively common soft tissue malignancy that is characterized by a specific chromosomal t(X;18)(p11;q11) translocation. Transducin-like enhancer of split 1 (TLE1) has emerged as a useful marker for the diagnosis of synovial sarcoma. However, the diagnostic value of this antibody remains controversial. We investigated TLE1 expression in sixty-two fluorescence in situ hybri...
متن کاملImmunohistochemical validation of TLE1, a novel marker, for synovial sarcomas
BACKGROUND & OBJECTIVES Logistic and financial constraints limit application of several available immunohistochemical (IHC) markers and molecular analysis in every case of synovial sarcoma, diagnosed in our settings. Recently, TLE1 has been recognized as a robust IHC marker for diagnosing a synovial sarcoma. Here, we present IHC features of synovial sarcomas, including TLE1 expression in these ...
متن کاملExpression profiling in soft tissue sarcomas with emphasis on synovial sarcoma, gastrointestinal stromal tumor, and leiomyosarcoma.
Sarcomas are defined as malignant neoplasms derived from mesenchymal tissues. A variety of different molecular approaches, including gene expression profiling, have identified candidate biomarkers and insights into sarcoma biology that will aid in the diagnosis and treatment of these tumors. Many gene expression profiling findings have been translated into immunohistochemical tests for diagnost...
متن کاملIntra-Articular Synovial Sarcomas: Incidence and Differentiating Features from Localized Pigmented Villonodular Synovitis
Purpose. To determine the incidence of intra-articular synovial sarcomas and investigate if any radiological variables can differentiate them from localized (unifocal) pigmented villonodular synovitis (PVNS) and if multivariate data analysis could be used as a complementary clinical tool. Methods. Magnetic resonance images and radiographs of 7 cases of intra-articular synovial sarcomas and 14 c...
متن کاملSynovial sarcomas of the head and neck: CT and MR findings.
The authors present three cases of histologically proved synovial sarcoma. CT is useful in assessing erosive or destructive changes in bone, and in demonstrating calcifications. MR characteristics are nonspecific; calcifications within these tumors can be missed on MR. MR can help to assess tumor extension, vascular invasion, and hemorrhage within the tumor.
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ژورنال
عنوان ژورنال: Clinical and Translational Gastroenterology
سال: 2012
ISSN: 2155-384X
DOI: 10.1038/ctg.2012.6